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007			cr nn 008mamaa
008			220601s2012 sz | s |||| 0|eng d
020			_a9783031025822
024	7		_a10.1007/978-3-031-02582-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP370 _b2012 EB
100	1		_aWilkinson, Ashley E. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9686404
245	1	0	_aCentral Nervous System Tissue Engineering : _bCurrent Considerations and Strategies _cby A. Wilkinson, Nic Leipzig, Aleesha McCormick
250			_a1st edition 2012
264		1	_aCham _bSpringer International Publishing _c2012
300			_a1 recurso en línea (VIII, 112 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aSynthesis Lectures on Tissue Engineering _x1944-0308
505	0		_aIntroduction -- Anatomy of the CNS and Progression of Neurological Damage -- Biomaterials for Scaffold Preparation -- Cell Sources for CNS TE -- Stimulation and Guidance -- Concluding Remarks.
520			_aCombating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks.
988			_aSynthesis Collection of Technology_2012
650		7	_2embne _9668849 _aTejidos (Biología)
650		7	_2embne _9144873 _aSistema nervioso central _xRegeneración
650		7	_2embne _9148273 _aRegeneración (Biología)
700	1		_aLeipzig, Nic D. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9686403
700	1		_aMcCormick, Aleesha M. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9686402
776	0	8	_iPrinted edition: _z9783031014543
776	0	8	_iPrinted edition: _z9783031037108
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-02582-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2023 _dz _esc _zSI