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020 _a9783319503530
024 7 _a10.1007/978-3-319-50353-0
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRA1199
_b2017 EB
245 0 0 _aAlternatives for Dermal Toxicity Testing
_cedited by Chantra Eskes, Erwin van Vliet, Howard I. Maibach
250 _a1st edition 2017
264 1 _aCham
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (XX, 592 páginas)
_b92 ilustraciones, 61 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
505 0 _aIntroduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.
520 _aThis book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
988 _aSpringer_Medicine_2017
650 7 _2embne
_9685999
_aEnsayos de toxicidad
650 7 _2embne
_9686000
_aTests cutáneos
650 7 _2embne
_9172093
_aPiel
_xEnfermedades
_xDiagnóstico
700 1 _aEskes, Chantra
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aVliet, Erwin van
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_9686001
700 1 _aMaibach, Howard I.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9783319503516
776 0 8 _iPrinted edition:
_z9783319503523
776 0 8 _iPrinted edition:
_z9783319843780
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-50353-0
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2023
_dz
_esc
_zSI