000			03199nam a2200469 i 4500
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003			ES-MaUEC
005			20230102122022.0
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007			cr nn 008mamaa
008			220503s2022 sz | o |||| 0|eng d
020			_a9783030948047
024	7		_a10.1007/978-3-030-94804-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH431 _b2022 EB
245	0	0	_aGadd45 Stress Sensor Genes _cedited by M. Raza Zaidi, Dan A. Liebermann
250			_a2nd edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (IX, 153 páginas) _b27 ilustraciones, 18 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x2214-8019 _v1360
505	0		_aGADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis -- GADD45 in Development and Cancer -- GADD45 in Normal Hematopoiesis and Leukemia -- GADD45 in DNA Methylation and DNA Repair -- GADD45 Proteins in Immunity -- GADD45 in Liver Function and Cancer -- GADD45 in Pre-Eclampsia -- GADD45 in Senescence -- GADD45 in Neuronal Development, Function, and Injury -- Index.
520			_aThis second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9140562 _aGenética humana
700	1		_aZaidi, M. Raza. _eeditor literario
700			_aLiebermann, Dan A. _eeditor literario _984854
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783030948030
776	0	8	_iPrinted edition: _z9783030948054
776	0	8	_iPrinted edition: _z9783030948061
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-94804-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2022 _dz _eb _zSI