000			04422nam a2200445 i 4500
999			_c382810 _d382810
001			382810
003			ES-MaUEC
005			20230102122018.0
006			a|||| o|||| 00| 0
007			cr nn 008mamaa
008			220413s2022 sz | o |||| 0|eng d
020			_a9783030944759
024	7		_a10.1007/978-3-030-94475-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA651 _b2022 EB
245	0	0	_aEpigenetic Epidemiology _cedited by Karin B. Michels
250			_a2nd edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XIV, 510 páginas) _b42 ilustraciones, 39 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aPart 1: Basic Concepts and Methodologic Considerations -- The Human Epigenome -- Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology -- Laboratory Methods in Epigenetic Epidemiology -- Biostatistical Methods in Epigenetic Epidemiology -- Epigenome Reprogramming During Development -- The Role of Epigenetics in the Developmental Origins of Health and Disease -- Epigenetics and Assisted Reproductive Technology -- Imprinting Disorders -- The Utility of Twins for Epigenetic Analysis -- Age-Related Variation in DNA Methylation -- The Epigenetic Clock -- Influence of Environmental Factors on the Epigenome -- Part 2: Epigenetic Epidemiology of Complex Diseases -- Epigenetic Epidemiology of Cancer -- Epigenetic Epidemiology of Infectious Diseases -- Epigenetic Epidemiology of Inflammation and Rheumatoid Arthritis -- Asthma Epigenetics: Emergence of a New Paradigm? -- Epigenetic Epidemiology of Autism and other Neurodevelopmental Disorders -- Epigenetic Epidemiology of Psychiatric Disorders -- Epigenetic Epidemiology of Obesity and Type 2 Diabetes -- Epigenetics and Vascular Disease (Atherosclerosis).
520			_aNow in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9138405 _aEpidemiología
650		7	_2embne _9144879 _aGenética médica
700	1		_aMichels, Karin B. _eeditor literario
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783030944742
776	0	8	_iPrinted edition: _z9783030944766
776	0	8	_iPrinted edition: _z9783030944773
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-94475-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2022 _dz _eb _zSI