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005			20230102122005.0
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007			cr nn 008mamaa
008			220625s2022 sz a s |||| 0|eng d
020			_a9783030993870
024	7		_a10.1007/978-3-030-99387-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC268.4 _b2022 EB
100			_aBunz, Fred _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9100653
245	1	0	_aPrinciples of Cancer Genetics _cby Fred Bunz
250			_a3rd edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XIII, 431 páginas) _b161 ilustraciones, 135 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aChapter 1. The Genetic Basis of Cancer -- Chapter 2. Oncogenes -- Chapter 3. Tumor Suppressor Genes -- Chapter 4. Genetic Instability and Cancer -- Chapter 5. Cancer Genomes -- Chapter 6. Cancer Gene Pathways -- Chapter 7. Cancer and the Immune System -- Chapter 8. Common Cancers and Their Genetic Alterations -- Chapter 9. Cancer Detection and Prognostication -- Chapter 10. Cancer Therapy.
520			_aThis popular textbook, now in its third edition, provides a theoretical framework for understanding why cancers arise, how they develop and how they can be treated. Particular attention is devoted to the origins of cancer and the application of evolutionary theory to explain how mutant cell populations tend to expand and spread. Focused on the genes and signaling pathways involved in the most common tumors, Principles of Cancer Genetics is a highly readable account that will be of interest to anyone who would like to attain a basic understanding of cancer biology. Students who have completed introductory coursework in genetics, biology and biochemistry, medical students and medical house staff will find this book to be a useful starting point toward mastery of this complex but fascinating topic. This updated edition delves into the critical interactions between growing tumors and the immune system, and introduces the concepts of T cell activation, immunoediting and immune evasion. Novel strategies for cancer diagnosis and prognosis, including new roles for next-generation sequencing and liquid biopsies, as well as established and emerging therapeutic modalities are now described in detail. For laypersons, students and researchers in other fields with a general interest in cancer, this book provides an accessible overview, enriched with many easy-to-understand illustrations. For advanced students considering future study in the field of oncology and cancer research, this concise book is a useful guide to the basic principles that underlie our understanding of cancer.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9273952 _aCáncer _xAspectos genéticos
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783030993863
776	0	8	_iPrinted edition: _z9783030993887
776	0	8	_iPrinted edition: _z9783030993894
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-99387-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2022 _dz _ek _zSI