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020 _a9783031012372
024 7 _a10.1007/978-3-031-01237-2
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQP535.P1
_b2022 EB
245 0 0 _aInorganic Polyphosphates .
_bFrom Basic Research to Medical Application
_cedited by Werner E. G. Müller, Heinz C. Schröder, Patrick Suess, Xiaohong Wang
250 _a1st edition 2022
264 1 _aCham
_bSpringer International Publishing
_c2022
300 _a1 recurso en línea (X, 189 páginas)
_b50 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aProgress in Molecular and Subcellular Biology
_x2197-8484
_v61
505 0 _aChapter 1. Inorganic Polyphosphate and F0F1-ATP Synthase of Mammalian Mitochondria -- Chapter 2. Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology -- Chapter 3. Inorganic Polyphosphate, Mitochondria, and Neurodegeneration -- Chapter 4. Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State -- Chapter 5. Biomimetic Polyphosphate Materials: Towards Application in Regenerative Medicine -- Chapter 6. Effects of Polyphosphate on Leukocyte Function -- Chapter 7. Polyphosphate in Antiviral Protection: A Polyanionic Inorganic Polymer in the Fight Against Coronavirus SARS-CoV-2 Infection.
520 _aThis volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers. In recent years, great advances have been made in understanding the development, metabolism, and physiological role of inorganic polyphosphates. These energy-rich polymers, which consist of long chains of phosphate units, are evolutionary old molecules. The acidocalcisomes, conserved organelles from bacteria to humans, as well as the mitochondria play a central role in polyphosphate production and storage. Polyphosphates have been assigned multiple functions, some of which are closely related to medically important processes, such as blood coagulation and fibrinolysis, energy metabolism, cell cycle regulation, apoptosis, chaperon function, microvascularization, stress response, neurodegeneration and aging. The development of bioinspired polyphosphate particles, in combination with suitable hydrogel-forming polymers enabled the development of new strategies in regenerative medicine, in particular for hard and soft tissue repair, but also in drug delivery and antimicrobial defense. This book not only highlights the basic research in this area, but also discusses possible applications. Therefore, it appeals to scientists working in cell biology, biochemistry, and biomedicine and practicioners alike.
988 _aSpringer_BiomedLife_2022
650 7 _2embne
_9138639
_aBioquímica
700 1 _aMüller, Werner E. G.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aSchröder, Heinz C.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aSuess, Patrick.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aWang, Xiaohong.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031012365
776 0 8 _iPrinted edition:
_z9783031012389
776 0 8 _iPrinted edition:
_z9783031012396
776 0 8 _iPrinted edition:
_z9783031034923
776 0 8 _iPrinted edition:
_z9783031034930
776 0 8 _iPrinted edition:
_z9783031034947
776 0 8 _iPrinted edition:
_z9783031034954
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-01237-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b09/2022
_dz
_ek
_zSI