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008			220606s2022 sz a s |||| 0|eng d
020			_a9783031065125
024	7		_a10.1007/978-3-031-06512-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH603.C43 _b2022 EB
245	0	0	_aToll-like Receptors in Health and Disease _cedited by Vijay Kumar
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (VIII, 314 páginas) _b100 ilustraciones, 30 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aHandbook of Experimental Pharmacology _x1865-0325 _v276
505	0		_aIntracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.
520			_aThe current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9139477 _aCitología
700	1		_aKumar, Vijay. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783031065118
776	0	8	_iPrinted edition: _z9783031065132
776	0	8	_iPrinted edition: _z9783031065149
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-06512-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2022 _dz _ek _zSI