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020 _a9789811668678
024 7 _a10.1007/978-981-16-6867-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 _aRC632.H65
_b2022 EB
245 1 0 _aHomocysteine Metabolism in Health and Disease
_cedited by Govind Prasad Dubey, Krishna Misra, Rajesh K. Kesharwani, Rudra P. Ojha.
250 _a1st edition 2022
264 1 _aSingapore
_bSpringer International Publishing
_c2022
300 _a1 recurso en línea (XX, 276 páginas)
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
505 0 _aModule 1 -- Nutrition and Health -- Module 2_Disease -- Module 3_Advanced Research .
520 _aThis book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.
988 _aSpringer_BiomedLife_2022
650 7 _2embne
_9168790
_aMetabolismo
_xTrastornos
700 1 _aDubey, Govind Prasad.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMisra, Krishna.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKesharwani, Rajesh K.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aOjha, Rudra P.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811668661
776 0 8 _iPrinted edition:
_z9789811668685
776 0 8 _iPrinted edition:
_z9789811668692
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-16-6867-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b09/2022
_dz
_ep
_zSI