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020			_a9789811660924
024	7		_a10.1007/978-981-16-6092-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA1211 _b2022 EB
100			_aChidambaram, Saravana Babu _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9683524
245	0	0	_aIntroduction to Toxicological Screening Methods and Good Laboratory Practice _cby Saravana Babu Chidambaram, M. Mohamed Essa, M. Walid Qoronfleh.
250			_aFirst edition 2022
264		1	_aSingapore _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XX, 189 páginas) _b1 ilustraciones
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aarchivo de texto _bPDF
505	0		_aChapter 1. Introduction to Toxicology -- Chapter 2. Laboratory Animal models -- Chapter 3. Toxicology Screening Methods -- Chapter 4. Toxicokinetics -- Chapter 5. Safety Pharmacology -- Chapter 6. Good Laboratory Practice.
520			_aThis book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule 'Y', India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9140328 _aToxicología
700	1		_aEssa, M. Mohamed _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _998418
700			_aQoronfleh, M. Walid _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9683525
776	0	8	_iPrinted edition: _z9789811660917
776	0	8	_iPrinted edition: _z9789811660931
776	0	8	_iPrinted edition: _z9789811660948
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-16-6092-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2022 _dz _ep _zSI