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020 _a9789811642548
024 7 _a10.1007/978-981-16-4254-8
_2doi
040 _aES-MaUEC
_bspa
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050 4 _aQP34
_b2021 EB
245 1 0 _aIon Channels in Biophysics and Physiology
_cedited by Lei Zhou.
250 _aFirst edition 2021
264 1 _aSingapore
_bSpringer International Publishing
_c2021
300 _a1 recurso en línea (VI, 413 páginas)
_b1 ilustraciones
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aarchivo de texto
_bPDF
490 0 _aAdvances in Experimental Medicine and Biology
_x2214-8019
_v1349
505 0 _aAdvancing ion channel research with automated patch clamp (APC) electrophysiology platforms -- Methods & Challenges to Study Mechanosensitive Ion Channels -- The Polysite Pharmacology of TREK K2P channels -- Physiological functions, biophysical properties and regulation of KCNQ1 (KV7.1) potassium channels -- Context matters - Calcium channel splice variants and their effects in brain and cardiovascular function -- Structure-function of TMEM16 ion channels and lipid scramblases -- Distribution and Assembly of TRP Ion Channels -- Regulation of Ion Channel Function by Gas Molecules -- DEG/ENaC ion channels in the function of the nervous system: from worm to man -- Glial chloride channels in the function of the nervous system across species -- Physiological and pathological relevance of selective and non-selective Ca2+ channels in skeletal and cardiac muscle -- Lysosomal TRPML1 Channel: Implications in Cardiovascular and Kidney Diseases -- Store-Operated Calcium Entry in the Cardiovascular System -- The role of thermosensitive ion channels in mammalian thermoregulation -- Mechanotransduction ion channels in hearing and touch -- The functional properties, physiological roles, channelopathy and pharmacological characteristics of the Slack (KCNT1) channel -- Ion Channels in Anesthesiology.
520 _aThis book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells from the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse function including secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, researches on ion channels carry significant meaning for the understanding of basic protein biophysics and diverse physiological functions and for developing novel and effective treatment for related human diseases. This book could provide graduates and scientists in both basic and clinical levels, a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.
988 _aSpringer_BiomedLife_2022
650 7 _2embne
_9140024
_aFisiología humana
700 _aZhou, Lei
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_9683518
776 0 8 _iPrinted edition:
_z9789811642531
776 0 8 _iPrinted edition:
_z9789811642555
776 0 8 _iPrinted edition:
_z9789811642562
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-16-4254-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
_n0
998 _b04/2022
_dz
_ep
_zSI