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008			220207s2021 sz | s |||| 0|eng d
020			_a9783030763671
024	7		_a10.1007/978-3-030-76367-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS400 _b2021 EB
245	1	0	_aOphthalmic Product Development : _bFrom Bench to Bedside _cedited by Seshadri Neervannan, Uday B. Kompella.
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (IX, 650 páginas) _b126 ilustraciones, 105 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aarchivo de texto _bPDF
490	0		_aAAPS Advances in the Pharmaceutical Sciences Series _x2210-738X _v37
505	0		_aIntroduction and History of Ophthalmic Product Development -- Ocular Surface Anatomy and Physiology: Impact on Product Development -- Anatomy and Physiology of the Anterior Chamber - Impact on Product Development -- Back of the eye anatomy & physiology - Impact on product development -- Physicochemical and Biological Fundamentals for Drug Delivery to the Eye -- Topical Ophthalmic Dosage Form Development - Key Components and Critical Quality Attributes -- Intra-ocular Injectable Dosage Form Development -- Microbiological Considerations for Ophthalmic Products - Sterility, Endotoxin Limits and Preservatives -- Packaging Development - Multi-dose container closure for preservative free products, extractable/leachables from packaging, new technologies -- Liquid ophthalmic drug products - physicochemical properties, formulations and manufacturing considerations -- Emulsions for topical eye delivery: state of the art and future perspectives -- Emulsions for topical eye delivery: state of the art and future perspectives -- Microparticle Products For The Eye - preformulation, formulation, and manufacturing considerations -- NANOPARTICLE PRODUCTS FOR THE EYE: preformulation, formulation and manufacturing considerations -- Advanced Hydrogel Formulations for the Eye -- Ophthalmic Product Development for Biologics -- Implantable Devices to Treat Ophthalmic Conditions -Drug Delivery Systems -- Development of Artificial Tears Products for Ocular Conditions -- Approval of Topical Ophthalmic Generic Products in the US - Simple to Complex Dosage Forms and Establishing Equivalency -- The development and commercialization of sustained-release ocular drug delivery technologies -- Manufacturing considerations and challenges for AAV Ocular Gene Therapy -- Transcorneal Kinetics of Topical Drugs and Nanoparticles.
520			_aThis is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.
988			_aSpringer_BiomedLife_2022
650		7	_2embne _9141808 _aQuímica farmacéutica
700			_aNeervannan, Seshadri _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _9683456
700			_aKompella, Uday B. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _9683457
776	0	8	_iPrinted edition: _z9783030763664
776	0	8	_iPrinted edition: _z9783030763688
776	0	8	_iPrinted edition: _z9783030763695
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-76367-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2022 _dz _ep _zSI