000 05207nam a22003855i 4500
999 _c367953
_d367953
_x1
001 367953
003 ES-MaUEC
005 20230102121653.0
006 a||||fo|||| 00| 0
007 cr nn 008mamaa
008 211220s2021 sz | s |||| 0|eng d
020 _a9783030805586
024 7 _a10.1007/978-3-030-80558-6
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aR850
_b2021 EB
245 1 0 _aTumor Suppressor Par-4 :
_bRole in Cancer and Other Diseases
_cedited by Vivek M. Rangnekar.
250 _aFirst edition 2021
264 1 _aCham
_bSpringer International Publishing
_c2021
300 _a1 recurso en línea (X, 331 páginas)
_b121 ilustraciones, 93 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aarchivo de texto
_bPDF
505 0 _aIntroduction. --Part 1 -- Chapter 1. Role of Par-4 in lung cancer -- Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma -- Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers -- Chapter 4. Regulation of Par-4 and role in GI tumors -- Chapter 5. Role of Par-4 in prostate cancer -- Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer -- Chapter 7. Role of Par-4 and GRP78 in Glioblastoma -- Chapter 8. Role of Par-4 in breast cancer recurrence -- Chapter 9. Involvement of Par-4 in breast cancer -- Chapter 10. Role of endogenous Par-4 in CLL -- Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth -- Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells -- Chapter 13. Par-4 expression in cholangiocarcinoma -- Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells -- Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target -- Chapter 16. Par-4 cleavage is required for TNF induced apoptosis -- Chapter 17. Par-4 secretagogues -- Chapter 18. Recombinant production and characterization of SAC -- Chapter 19. Anti-tumor effects of plant derived Par-4 -- Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages -- Part 2 - Role in other Diseases -- Chapter 21. Role of Par-4 in ceramide inducible effects in neurons -- Chapter 22. Role of Par-4 in Alzheimers disease -- Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression -- Chapter 24. Par-4 (PAWR) in major depressive disorder -- Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes -- Chapter 26. Par-4 in cardiac fibroblast senescence -- Chapter 27. Par-4 in ocular development and disease -- Chapter 28. Par-4 in apoptosis during human salivary gland development -- Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis -- Chapter 30. Lessons from knockout mice -- Part 3 - From Bench to Bedside -- Chapter 31. Par-4 secretagogues in clinical trials -- Chapter 32. Potential of Par-4 as a therapeutic target for cancer.
520 _aPar-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer's and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4's role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
988 _aSpringer_BiomedLife_2022
650 7 _2embne
_9146841
_aMedicina experimental
700 _aRangnekar, Vivek M.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_9683003
776 0 8 _iPrinted edition:
_z9783030805579
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-80558-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
_n0
998 _b03/2022
_dz
_ep
_zSI