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008			211020s2021 si a s |||| 0|eng d
020			_a9789811645211
024	7		_a10.1007/978-981-16-4521-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC280.B8 _b2021 EB
245	0	0	_aHereditary Breast and Ovarian Cancer . _bMolecular Mechanism and Clinical Practice _cedited by Seigo Nakamura, Daisuke Aoki, Yoshio Miki
250			_aFirst edition 2021
264		1	_aSingapore _bSpringer International Publishing _c2021
264		4	_c2021
300			_a1 recurso en línea (VIII, 324 páginas) _b31 ilustraciones, 24 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
505	0		_a1 History, Advancements, and Future Strategies -- 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis -- 3 Genetic Testing -- 4 Variants of uncertain significances in hereditary breast and ovarian cancer -- 5 Genetic counseling in Hereditary Breast and Ovarian Cancer -- 6 Hereditary Breast Cancer -- 7 Hereditary Ovarian Cancer -- 8 Risk-Based Breast Cancer Screening -- 9 Chemoprevention for Breast Cancer -- 10 Chemoprevention for Ovarian Cancer -- 11 Risk-Reducing Mastectomy (RRM) -- 12 Risk-reducing salpingo-oophorectomy (RRSO) -- 13 Panel Testing -- 14 Germline Findings through Precision Oncology for Ovarian Cancer -- 15 Germline Findings from Genetic Testing for Breast Cancer -- 16 Hereditary Breast and Ovarian Cancer (HBOC) Database -- 17 Ethical Issues: Overview in Genomic analysis and Clinical Context -- 18 PARP Inhibitors-Mechanism of action -- 19 PARPi - Efficacy in Hereditary Breast Cancer -- 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer.
520			_aThis highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.
988			_aSpringer_Medicine_2021
650		7	_2embne _9225524 _aOvarios _xCáncer
650		7	_2embne _9273952 _aCáncer _xAspectos genéticos
700	1		_aNakamura, Seigo _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aAoki, Daisuke _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMiki, Yoshio _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811645204
776	0	8	_iPrinted edition: _z9789811645228
776	0	8	_iPrinted edition: _z9789811645235
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-16-4521-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2022 _dz _ek _zSI