000			03271nam a2200421 i 4500
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003			ES-MaUEC
005			20230102121620.0
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007			cr nn 008mamaa
008			210510s2021 sz | o |||| 0|eng d
020			_a9783030725990
024	7		_a10.1007/978-3-030-72599-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC270.8 _b2021 EB
100	1		_aLittle, Melvyn, _d1945- _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9682215
245	1	0	_aAntibodies for Treating Cancer : _bBasics, Development, and Applications _cby Melvyn Little
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (XI, 151 páginas) _b34 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
505	0		_a1 Life-saving antibodies - history of immunization -- 2 Current approaches for immunising against cancer -- 3 Function and Structure of antibodies -- 4 Of mice and men - production of therapeutic antibodies -- 5 Novel modular antibodies -- 6 Antibodies as "Magic Bullets" -- 7 Mediation of tumor cell destruction -- 8 Engagement of immune killer cells -- 9 Approved antibodies for cancer therapy -- 10 Bringing therapeutic antibodies on the market -- 11 Future developments - outlook.
520			_aThis book presents a compact overview of the history, evolution and fascinating novel applications of antibodies for the treatment of cancer, leading the reader step by step to the latest advances. Interesting anecdotes, together with self-explanatory and clearly structured figures with a humorous touch, facilitate the reader's understanding of this complex topic. Clinical cases round out the book, making it a valuable aid for professionals in their everyday practice. The growing importance of the topics covered here was highlighted by the joint award of the 2018 Nobel Prize in Chemistry to Frances H. Arnold (directed evolution of enzymes), George P. Smith (phage display of peptides) and Sir Gregory P. Winter (phage display of antibodies). Furthermore, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. Many of the antibodies that are now being brought to market target precisely these immune checkpoint modulators. The book addresses a broad readership, ranging from professionals and experts in the field to residents and medical students.
988			_aSpringer_Medicine_2021
650		7	_2embne _9174085 _aCáncer _xTratamiento
776	0	8	_iPrinted edition: _z9783030725983
776	0	8	_iPrinted edition: _z9783030726003
776	0	8	_iPrinted edition: _z9783030726010
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-72599-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2022 _dz _eb _zSI