000			04083nam a2200433 i 4500
999			_c362801 _d362801 _x1
001			362801
003			ES-MaUEC
005			20230102121618.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			210810s2021 sz a s |||| 0|eng d
020			_a9783319894973
024	7		_a10.1007/978-3-319-89497-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC648 _b2021 EB
245	0	0	_aPolyendocrine Disorders and Endocrine Neoplastic Syndromes _cedited by Annamaria Colao, Marie-Lise Jaffrain-Rea, Albert Beckers
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
264		4	_c2021
300			_a1 recurso en línea _bilustraciones
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aEndocrinology _x2510-1935
505	0		_aIntroduction.-Auto-immune polyglandular syndromes (APS): an overview -- The natural history of APS1: pathogenesis and long term follow-up -- The genetics of AIRE: an update -- Auto-antibodies in polyendocrine auto-immune disorders: an update -- Rare forms of endocrine and systemic auto-immune disorders: IPEX and "other POEMS" -- Auto-immune endocrine diseases and cancer immunotherapy -- Part 2: MEN1: an update on molecular diagnosis and clinical implications -- MEN2: an update on molecular diagnosis and clinical implications -- MEN4 and other MEN1-like syndrome -- Genetic alterations in the cAMP pathway: MAS, Carney complex (and AIP?) -- Endocrine tumours associated with SDHx mutations: pheochromocytomas, paragangliomas and pituitary adenomas -- Endocrine tumours in complex genetic disorders: lessons from pheochromocytomas and hyperparathyroidism.
520			_aThis comprehensive reference book is meant to support clinicians in the diagnosis and treatment of polyendocrine diseases and endocrine neoplastic syndromes. Although a large majority of endocrine diseases present as sporadic cases, an increasing proportion can be identified as part of a polyendocrine or systemic syndrome. These include autoimmune endocrine diseases, which may be part of autoimmune polyendocrine disorders (APS) or rare complex disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) or IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndromes. On the other hand, endocrine tumors may develop in a variety of clinical conditions, including multiple endocrine neoplasia (MEN) syndromes, syndromic diseases such as McCune Albright or Carney's complex, or peculiar familial associations such as pheochromocytoma/paraganglioma syndromes. The book discusses the significant advances that have been made in the clinical and genetic characterization of such entities, with major implications in terms of diagnosis and clinical management - with special attention to emerging syndromes, familial screening , multidisciplinarity and multimodal treatment. This volume is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients, including specialists in endocrinology, internal medicine, oncology , genetics and imaging. .
988			_aSpringer_Medicine_2021
650		7	_2embne _9139372 _aEndocrinología
700	1		_aColao, Annamaria _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aJaffrain-Rea, Marie-Lise _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBeckers, Albert _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783319894966
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-89497-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2022 _dz _ek _zSI