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008			210317s2021 sz | o |||| 0|eng d
020			_a9783030675219
024	7		_a10.1007/978-3-030-67521-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC771 _b2021 EB
245	0	0	_aNeuroimaging of Covid-19 : _bFirst Insights based on Clinical Cases _cedited by Simonetta Gerevini M.D.
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (VII, 93 páginas) _b68 ilustraciones, 8 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
505	0		_aIntroduction -- Background -- Vascular manifestation in COVID-19 -- Posterior reversible encephalopathy syndrome (PRES) and meningo encephalitis -- Possibile thrombotic microangiopathy occurring in patient with CNS localization of SARS-Cov-2 -- Future directions.
520			_aThis book presents the variability of the effects of Covid-19 on the nervous system (NS), with the purpose to update content and images based on improved scientific evidence. Current available data show that involvement of the NS is frequent in patients with SARS-CoV-2 infection. The most common neurologic syndromes include cerebrovascular disorders, encephalopathies, inflammatory Central Nervous System (CNS) syndromes, peripheral neurologic disorders, psychiatric disorders. The pathophysiology of neurological manifestations is far from being understood. They can be coincidental, common complications of severe viral infection, or direct consequence of the viral infection either via indirect para-infective mechanisms or direct viral penetration of NS. Experimental animal models had previously demonstrated the neuroinvasive potential of SARS-CoV and the detection of viral particles in special structures such as the thalamus, nucleus ambiguous and nucleus of the solitary tract, suggesting that CNS invasion can contribute significantly to the severe outcome not only through direct damage to neurological structures, but also through a potential detrimental effect on cardiorespiratory responses. Up to now, the detection of SARS-CoV-2 RNA in the cerebrospinal fluid of COVID-19 patients has been reported occasionally and conclusive pathological demonstration of the virus in the CNS is lacking. In this scenario, the role of neuroimaging is fundamental. These considerations highlight the urgent need to better clarify the neurotropic potential of the SARS-CoV-2 virus, and to verify on human autoptic tissue the mechanisms demonstrated in the experimental animal model in order to develop potential strategies to prevent CNS invasion and to adapt treatment protocols based on neurological involvement. CT scan is useful to detect large hemorrhage and ischemic lesions, that have been reported in Covid-19 patients, but lacks identifying other possible neurological complications, such as microhemorrhage or encephalitis. MRI could overcome these limitations; in particular the use of specific sequences may reveal microvascular lesions that can occur during the disease course, according to the described pathogenesis. This book will be an invaluable tool for neuroradiologists, radiologists, neurologists, and all physicians involved in the pandemic.
988			_aSpringer_Medicine_2021
650		7	_2embne _9144209 _aNeumonía
650		7	_2embne _aCOVID-19 _9683668
700	1		_aGerevini M.D., Simonetta. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030675202
776	0	8	_iPrinted edition: _z9783030675226
776	0	8	_iPrinted edition: _z9783030675233
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-67521-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2022 _dz _eb _zSI