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008			211126s2021 sz | o |||| 0|eng d
020			_a9783030860165
024	7		_a10.1007/978-3-030-86016-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR181 _b2021 EB
245	0	0	_aBone Marrow Niche : _bMicroenvironments Critical for Immune Cell Development _cedited by Takashi Nagasawa
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (VII, 134 páginas) _b19 ilustraciones, 17 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aCurrent Topics in Microbiology and Immunology _x2196-9965 _v434
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aPreface -- Skeletal stem cells as the developmental origin of cellular niches for hematopoietic stem and progenitor cells -- Cellular niches for hematopoietic stem cells and lympho-hematopoiesis in bone marrow during homeostasis and blood cancers -- Remodeling of the bone marrow stromal microenvironment during pathogenic infections -- The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs -- Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches -- Immune Niche within the Peritoneal Cavity.
520	3		_aThis volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
988			_aSpringer_BiomedLife_2021
650		7	_2embne _aInmunología _9138330
650		7	_2embne _aCélulas _9139475
700	1		_aNagasawa, Takashi _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _9680464
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-86016-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2022 _dz _eb _zSI