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020			_a9789811617577
024	7		_a10.1007/978-981-16-1757-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRB131 _b2021 EB
100			_aMaru, Yoshiro _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9100465
245	1	0	_aInflammation and Metastasis _cby Yoshiro Maru
250			_aSecond edition 2021
264		1	_aSingapore _bSpringer International Publishing _c2021
300			_a1 recurso en línea (XX, 518 páginas) _b81 ilustraciones, 33 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aChapter 1 General Thinking About Inflammation -- Chapter 2 Inflammation from the Standpoint of Leukocytes -- Chapter 3 Vessels and Coagulation -- Chapter 4 Sterile Inflammation -- Chapter 5 Issue of Self and Non-self -- Chapter 6 Extension of Endogenous Field -- Chapter 7 Evidence for Existence of Endogenous TLR4 Ligands -- Chapter 8 Autoinflammatory Disorders -- Chapter 9 Cancer in General -- Chapter 10 Basic Research -- Chapter 11 Tumor Microenvironment -- Chapter 12 Whole-Body Matter -- Chapter 13 Premetastatic Microenvironment -- Chapter 14 What Is Homeostasis? -- Chapter 15 Explanation of Metastasis by Homeostatic Inflammation -- Chapter 16 Therapeutic Potential.
520	3		_aThis book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.
988			_aSpringer_BiomedLife_2021
650		7	_2embne _9153270 _aInflamación
650		7	_2embne _9413460 _aMetástasis
776	0	8	_iPrinted edition: _z9789811617560
776	0	8	_iPrinted edition: _z9789811617584
776	0	8	_iPrinted edition: _z9789811617591
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-16-1757-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2022 _dz _eb _zSI