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020 _a9783030734534
024 7 _a10.1007/978-3-030-73453-4
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQP551
_b2021 EB
245 0 0 _aProteoglycans in Stem Cells :
_bFrom Development to Cancer
_cedited by Martin Götte, Karin Forsberg-Nilsson
250 _aFirst edition 2021
264 1 _aCham
_bSpringer International Publishing
_c2021
300 _a1 recurso en línea (XI, 308 páginas)
_b51 ilustraciones, 46 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aBiology of Extracellular Matrix
_x2191-1959
_v9
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aChapter 1: Heparan Sulfate Proteoglycans in the Stem Cell Niche: Lessons from Drosophila -- Chapter 2: Proteoglycans in zebrafish development -- Chapter 3: The pivotal role of versican turnover by ADAMTS proteases in mammalian reproduction and development -- Chapter 4: Use of chondroitin sulfate to aid in vitro stem cell differentiation -- Chapter 5: Regulatory functions of heparan sulfate in stem cell self-renewal and differentiation -- Chapter 6: Proteoglycans as mediators of neurogenesis and stem cell differentiation -- Chapter 7: Syndecan-3: a signaling conductor in the musculoskeletal system -- Chapter 8: Proteoglycans of the neural stem cell niche -- Chapter 9: Heparan sulfate in normal and cancer stem cells of the brain -- Chapter 10: Hyaluronic acid-CD44 interaction in the physio- and pathological stem cell niche -- Chapter 11: Proteoglycans in glioma stem cells -- Chapter 12: Role of Syndecan-1 in Cancer Stem cells.
520 3 _aThis book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
988 _aSpringer_BiomedLife_2021
650 7 _2embne
_aProteínas
_9139861
650 7 _2embne
_aCélulas madre
_9160528
700 1 _aGötte, Martin.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aForsberg-Nilsson, Karin.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9783030734527
776 0 8 _iPrinted edition:
_z9783030734541
776 0 8 _iPrinted edition:
_z9783030734558
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-73453-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2022
_dz
_eb
_zSI