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008			210927s2021 sz | o |||| 0|eng d
020			_a9783030840525
024	7		_a10.1007/978-3-030-84052-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP531 _b2021 EB
245	0	0	_aPharmacology of Potassium Channels _cedited by Nikita Gamper, KeWei Wang.
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (VIII, 545 páginas) _b70 ilustraciones
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aHandbook of Experimental Pharmacology _x1865-0325 _v267
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aComparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
520	3		_aThe aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
988			_aSpringer_BiomedLife_2021
650		7	_2embne _9668476 _aQuímica bioorgánica
650		7	_2embne _aFarmacología _9137893
700	1		_aGamper, Nikita. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aWang, KeWei. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030840518
776	0	8	_iPrinted edition: _z9783030840532
776	0	8	_iPrinted edition: _z9783030840549
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-84052-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2022 _dz _eb _zSI