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008			210908s2021 sz | o |||| 0|eng d
020			_a9783030701154
024	7		_a10.1007/978-3-030-70115-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP551 _b2021 EB
245	0	4	_aThe Role of Glycosylation in Health and Disease _cedited by Gordan Lauc, Irena Trbojević-Akmačić
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (XXV, 376 páginas) _b45 ilustraciones, 36 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x2214-8019 _v1325
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aN-glycosylation -- Mucin type O-GalNAc glycosylation in health and disease -- Glycosphingolipids -- Glycosaminoglycans -- Other types of glycosylation -- Extracellular vesicles and glycosylation -- Quantitative genetics of human protein N-glycosylation -- Epigenetic regulation of glycosylation -- Glycosaminoglycans in neurodegenerative diseases -- Glycosylation in autoimmune diseases -- The role of glycosylation in infectious diseases -- The importance of glycosylation in COVID-19 infection -- The role of glycosylation in inflammatory diseases -- Protein glycosylation in diabetes -- Glycosylation and cardiovascular diseases -- Glycosylation profiling as a biomarker of suboptimal health for chronic disease stratification -- Glycosylation and aging.
520	3		_aGlycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans' functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
988			_aSpringer_BiomedLife_2021
650		7	_2embne _aProteínas _9139861
650		7	_2embne _9146841 _aMedicina experimental
700	1		_aLauc, Gordan. _eeditor literario _0(orcid)0000-0003-1840-9560 _1https://orcid.org/0000-0003-1840-9560 _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aTrbojević-Akmačić, Irena. _eeditor literario _0(orcid)0000-0003-0106-0155 _1https://orcid.org/0000-0003-0106-0155 _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030701147
776	0	8	_iPrinted edition: _z9783030701161
776	0	8	_iPrinted edition: _z9783030701178
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-70115-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2022 _dz _eb _zSI