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020 _a9783030621292
024 7 _a10.1007/978-3-030-62129-2
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQH603.P45
_b2021 EB
245 0 0 _aBiology of Pericytes .
_bRecent Advances
_cedited by Alexander Birbrair
250 _aFirst edition 2021
264 1 _aCham
_bSpringer International Publishing
_c2021
264 4 _c2021
300 _a1 recurso en línea (XI, 278 páginas)
_b51 ilustraciones
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aStem Cell Biology and Regenerative Medicine
_x2196-8993
_v68
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aIn Vivo Optical Imaging and Manipulation of Brain Pericytes -- The complex and integral roles of pericytes within the neurovascular unit in health and disease -- Role of pericytes in brain metastasis -- Effects of Cytomegalovirus on Pericytes -- Pericytes in Retinal Ischemia -- Inflammatory mediators released by brain pericytes as sensors and effectors in blood-brain barrier dysfunction -- TLR-4 signaling in Pericytes -- EphA7+ Multipotent Pericytes and Their Roles in Multicellular Organisms -- Skeletal Muscle-Resident Pericyte Responses to Conditions of Use and Disuse -- Pericytes in myocardial diseases -- Adventitial and skeletal muscle pericytes in health and in ischemic tissue regeneration.
520 3 _aPericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other more well studied cell types, and revealed key signals derived from pericytes involved in homeostasis, regeneration, and disease regulation. In the last ten years, several unexpected roles of pericytes have been discovered. It has been demonstrated that pericytes from different tissues differ in their properties as well as functions. Even more, pericytes are heterogeneous also within the same organ. This book is will describe the major contributions of pericytes to different organs biology in physiological and pathological conditions. The book will teach the readers about this so special cell type that 10 years ago was almost completely forgotten, and it was associated basically only with vascular stability. Recently, it become a very hot topic to work in. Several articles in Nature, Science and Cell have been and are being currently published about this cell type. These recent works are revealing how important those cells are for before unimaginable biological processes. Thus, this book will update us on what are the most novel functions attributed to these cells. Also, will introduce to the young generation all the history about these cells from when they were discovered in different organs till where we are now in this field. So it will be a great book for both cell biology students as well as researchers that will have an update on these cells biology in different organs.
988 _aSpringer_BiomedLife_2021
650 7 _2embne
_aCitología
_9139477
700 1 _aBirbrair, Alexander.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9783030621285
776 0 8 _iPrinted edition:
_z9783030621308
776 0 8 _iPrinted edition:
_z9783030621315
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-62129-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2022
_dz
_ek
_zSI