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005			20230102121303.0
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007			cr nn nnnaamaa
008			210704s2021 sz a s |||| 0|eng d
020			_a9783030765712
024	7		_a10.1007/978-3-030-76571-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP623 _b2021 EB
245	0	0	_aRNA Damage and Repair _cedited by Ioly Kotta-Loizou.
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
264		4	_c2021
300			_a1 recurso en línea (IX, 178 páginas) _b25 ilustraciones, 22 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aPart 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.
520	3		_aRibonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.
988			_aSpringer_BiomedLife_2021
650		7	_2embne _9144940 _aARN
700	1		_aKotta-Loizou, Ioly. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030765705
776	0	8	_iPrinted edition: _z9783030765729
776	0	8	_iPrinted edition: _z9783030765736
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-76571-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2022 _dz _ek _zSI