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008			210312s2021 sz a s |||| 0|eng d
020			_a9783030670481
024	7		_a10.1007/978-3-030-67048-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552.C62 _b2021 EB
245	0	4	_aThe Collectin Protein Family and Its Multiple Biological Activities _cedited by Uday Kishore, Taruna Madan, Robert B. Sim
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
264		4	_c2021
300			_a1 recurso en línea (XII, 244 páginas) _b50 ilustraciones, 45 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_a1. Discovering the role of mannose-binding lectin (MBL) in innate immunity: the early history -- 2. Mannose-binding lectin in human health and disease -- 3. The activities of MASPs, complement proteases associated with collectins and ficolins -- 4. Structures of the MASPs and comparison with C1r and C1s -- 5. Biological activities of SP-A and SP-D against extracellular and intracellular pathogens -- 6. Surfactant protein D: A Therapeutic Target for Allergic Airway Diseases -- 7. SP-D in immune surveillance against cancer -- 8.Testicular immune privilege - a recently discovered domain of Collectins -- 9. Role of Collectins in Pregnancy -- 10. Bovine Collectins: Role in Health and Disease -- .
520	3		_aThe topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: · Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. · Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. · The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. · Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.
988			_aSpringer_BiomedLife_2021
650		7	_2embne _aProteínas _9139861
700	1		_aKishore, Uday. _eeditor literario _0(orcid)0000-0002-6033-6759 _1https://orcid.org/0000-0002-6033-6759 _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMadan, Taruna. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aSim, Robert B. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030670474
776	0	8	_iPrinted edition: _z9783030670498
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-67048-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2022 _dz _ek _zSI