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020 _a9789813347618
024 7 _a10.1007/978-981-33-4761-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC157
_b2021 EB
100 1 _aQidwai, Tabish
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_9680571
245 1 0 _aExploration of Host Genetic Factors associated with Malaria
_cby Tabish Qidwai
250 _aFirst edition 2021
264 1 _aSingapore
_bSpringer International Publishing
_c2021
264 4 _c2021
300 _a1 recurso en línea (XI, 172 páginas)
_b79 ilustraciones, 48 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aChapter 1. Human genetics and infectious disease -- Part 1. RBC disorders -- Chapter 2. Sickle cell gene -- Chapter 3. Alpha-Thalassemia -- Chapter 4. Beta-Thalassemia -- Chapter 5. Duffy blood group locus -- Part 2. Metabolic enzymes -- Chapter 6. Pyruvate kinase deficiency -- Chapter 7. Glucose 6-Phosphate dehydrogenase -- Part 3. Host immune response -- Chapter 8. TNF genetic polymorphisms -- Chapter 9. iNos genetic polymorphisms -- Chapter 10. Human complement receptor 1 polymorphisms -- Chapter 11. Interferonalpha receptor-1 (IFNAR1) polymorphisms -- Part 4. Cytoadherence -- Chapter 12. Intercellular adhesion molecule-1 polymorphisms -- Chapter 13. Platelet endothelial cell adhesion molecule-1 (PECAM-1) polymorphisms -- Chapter 14. Vascular cell adhesion molecule-1 (VCAM1) polymorphisms.
520 3 _aThis book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.
988 _aSpringer_BiomedLife_2021
650 7 _2embne
_aPaludismo
_9672093
776 0 8 _iPrinted edition:
_z9789813347601
776 0 8 _iPrinted edition:
_z9789813347625
776 0 8 _iPrinted edition:
_z9789813347632
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-33-4761-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2022
_dz
_ek
_zSI