000			03003nam a22003735i 4500
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
988			_aSpringer_Medicine_2018
999			_c343865 _d343865 _x1
001			343865
003			ES-MaUEC
005			20230102120149.0
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
008			180908s2018 gw | s |||| 0|eng d
020			_a9783319952345
024	7		_a10.1007/978-3-319-95234-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
050		4	_aRC280.S8 _b2018 EB
245	1	0	_aDiffuse Gastric Cancer _cedited by Tiago Biachi de Castria, Rodrigo Santa Cruz Guindalini.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2018
300			_a1 recurso en línea (X, 81 páginas) _b9 ilustraciones, 6 ilustraciones a color
490			_aMedicine (Springer-11650)
505	0		_a1. Introduction -- 2. Epidemiology -- 3. The Role of Endoscopy -- 4. Pathology and Molecular Biology -- 5. Genetic Predisposition and Hereditary Syndromes -- 6. The Role of Surgery -- 7. The Role of Radiotherapy -- 8. The Role of Chemotherapy.
520			_aWe live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
650		7	_2embne _9670603 _aEstómago _xCáncer
700	1		_ade Castria, Tiago Biachi. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGuindalini, Rodrigo Santa Cruz. _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783319952338
776	0	8	_iPrinted edition: _z9783319952352
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-95234-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_aSI _a_alco _a_vill _b02/2019 _cm _dz _feng _ggw _h0