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008			210131s2021 gw a o |||| 0|eng d
020			_a9783030638177
024	7		_a10.1007/978-3-030-63817-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _erda _dES-MaUEC
050		4	_aR857.M3 _b2021 EB
100	1		_aJoshi, Rucha _eautor _0(orcid)0000-0002-0456-233X _1https://orcid.org/0000-0002-0456-233X _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aCollagen Biografts for Tunable Drug Delivery _cby Rucha Joshi.
250			_aFirst edition 2021
264		1	_aCham _bSpringer International Publishing _c2021
300			_a1 recurso en línea (XII, 107 páginas) _b41 ilustraciones, 30 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aarchivo de texto _bPDF
490	0		_aSpringerBriefs in Applied Sciences and Technology _x2191-530X
490	0		_aEngineering (SpringerNature-11647)
490	0		_aEngineering (R0) (SpringerNature-43712)
505	0		_aIntroduction -- Creating Tunable Collagen Matrices - An Approach Inspired by In-Vivo Collagen Synthesis and Self-Assembly -- Application of Collagen Fibril Biografts for Enhancing Local Vascularization in an In-Vivo Chick Chorioallantoic Membrane (CAM) Model -- Appendix A: Type I Collagen Based Drug Delivery Formats -- Appendix B: State-of-the-Art Methods of Tuning Collagen Based Molecular Release.
520	3		_aThis book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.
988			_aSpringer_Engineering_2021
650		7	_2embne _aMateriales biomédicos _xUso terapéutico _9150723
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-63817-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE _n0
998			_b04/2021 _dz _eb _zSI