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020 _a9783030602048
024 7 _a10.1007/978-3-030-60204-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC627.8
_b2020 EB
245 0 0 _aPeroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases
_cedited by Gérard Lizard.
250 _aFirst edition 2020
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2020.
300 _a1 recurso en línea (X, 212 páginas)
_b44 ilustraciones, 38 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v1299
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aChapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer's disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer's disease, Mild Cognitive Impairment and Parkinson's disease in conjunction with a new hypothesis for the etiology of Alzheimer's disease.
520 3 _aThis book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
988 _aSpringer_BiomedLife_dic2020
650 7 _2embne
_9156016
_aEnfermedades hereditarias metabólicas
650 7 _2embne
_9158842
_aEnfermedades neurodegenerativas
700 1 _aLizard, Gérard
_eeditor literario
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783030602031
776 0 8 _iPrinted edition:
_z9783030602055
776 0 8 _iPrinted edition:
_z9783030602062
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-60204-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2021
_dz
_ea
_zSI