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020 _a9783030544904
024 7 _a10.1007/978-3-030-54490-4
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aBF724.55.A35
_b2020 EB
050 4 _aRS190-210
_b2020 EB
245 0 0 _aSystemic Delivery Technologies in Anti-Aging Medicine:
_bMethods and Applications
_cedited by Wing-Fu Lai.
250 _aFirst edition 2020
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2020.
300 _a1 recurso en línea (XVI, 511 páginas)
_b128 ilustraciones, 100 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aHealthy Ageing and Longevity
_x2199-9007
_v13
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aPreface -- Part I: Fundamentals of Systemic Delivery -- Anti-aging medicine: new concepts and intervention development,- Roles of systemic delivery in the development of anti-aging therapies -- Pharmacokinetics and pharmacodynamics in drug delivery -- Physiological, biochemical, and chemical barriers to systemic delivery -- Partt II: Development of Delivery Technologies for Systemic Delivery -- Use of prodrugs for systemic delivery in anti-aging medicine -- Use of physical methods for systemic delivery in anti-aging medicine -- Use of viral systems for systemic delivery in anti-aging medicine -- Use of non-viral biological systems for systemic delivery in anti-aging medicine -- Use of lipid-based systems for systemic delivery in anti-aging medicine -- Use of polymeric systems for systemic delivery in anti-aging medicine -- Use of inorganic nanoparticles for systemic delivery in anti-aging medicine -- Part III: Practical Considerations in Intervention Execution -- Strategies in carrier design to enhance systemic delivery -- Characterization techniques for studying the properties of the carriers -- In vivo assessment of the efficiency of systemic delivery in anti-aging medicine -- Selection of administration routes for systemic delivery in anti-aging medicine -- Intellectual property and regulatory issues in drug delivery research -- Index.
520 3 _aThis book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.
988 _aSpringer_BiomedLife_dic2020
650 7 _2embne
_9141231
_aEnvejecimiento
700 1 _aLai, Wing-Fu
_eeditor literario0(orcid)0000-0003-0585-6396
_1https://orcid.org/0000-0003-0585-6396
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783030544898
776 0 8 _iPrinted edition:
_z9783030544911
776 0 8 _iPrinted edition:
_z9783030544928
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-54490-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2021
_dz
_eIG
_zSI