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020 _a9783030586775
024 7 _a10.1007/978-3-030-58677-5
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC682.9
_b2020 EB
245 0 0 _aSex Differences in Heart Disease
_cedited by Bohuslav Ostadal, Naranjan S. Dhalla
250 _aFirst edition 2020
264 1 _aCham
_bSpringer International Publishing
_c2020
300 _a1 recurso en línea (XVI, 284 páginas)
_b47 ilustraciones, 15 ilustraciones en color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aAdvances in Biochemistry in Health and Disease ;
_v21
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aThe role of sex in cardiac function and disease -- Sex based differences in cardiac ischemic injury and reperfusion -- Sex differences in myocardial infarct size -- Sex differences in the susceptibility to ischemic injury - the role of calcium loading and adrenergic stimulation -- Sex and obesity and myocardial tolerance to ischemia -- Effect of female sex on rat ventricular myocytes exposed to stimulated ischemia -- Cardioprotection in females -- Sex differences in Cardioprotection ischemia reperfusion injury -- Sex and ischemic preconditioning -- Postconditioning and female heart -- Prenatal hypoxia and sex-dependent increase in heart susceptibility in adults -- Sex and cardiovascular system -- Sex differences in coronary heart disease -- Sex differences in the management of non-ST-elevation acute coronary syndrome -- Sex specific aspects of coronary heart disease risk factors -- Sex differences in patients with ischemic heart failure undergoing surgical treatment -- Woman and the management of acute coronary syndrome -- Sex differences and heart hypertrophy and failure -- Sex differences among patients with acute coronary syndrome undergoing PTCA -- Sex differences and atherosclerosis -- Estrogen and cardiovascular system -- Estrogen signaling and cardiovascular disease -- A novel estrogen receptor GPER and its role in the protection against ischemia/reperfusion injury -- Sexual hormones: effects on mitochondrial activity after ischemia/reperfusion injury -- Progesterone and ischemia/reperfusion injury -- Testosteron and myocardial infarction -- Postmenopausal hormone therapy: risks and benefits -- Molecular and cellular basis of cardiovascular sex differences -- Mitochondria - a target for sex differences in cardiac pathology -- Sex differences in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load -- Sex differences in mitochondrial biogenesis -- Sexual dimorphism in the expression of mitochondria-related genes in rat heart -- Sex differences in mitochondrial antioxidant gene expression -- Sex differences in the regulation of mitochondrial subpopulations -- Sex specificities in Ca handling in cardiac mitochondria -- The influence of exercise and sex on mitochondrial metabolism and ultrastructure -- Sex differences in the phosphorylation of mitochondrial proteins - effect on cardioprotection -- Sex - specific proteomic alterations in mitochondrial pathways.
520 3 _aCardiovascular diseases are the leading cause of mortality in men and women. Unfortunately, women have traditionally been excluded from clinical trials, and female animals have been used less or sex was not reported in basic research studies. Until recently, consideration of both sexes was not required in clinical and preclinical studies focusing on cardiovascular diseases. However, the number of clinical and experimental papers dealing with sex differences and heart disease significantly increases during the last years. This trend is obviously the result of at least two facts: the number of examples of different behavior of the male and female heart under physiological and pathological conditions is steadily increasing and there were controversial reports on the beneficial and adverse effect of hormonal replacement therapy. Detailed molecular and cellular mechanisms of these differences are still unknown but one is clear already today: sex differences are so important that they should be considered by the selection of optimum diagnostic and therapeutic procedures in clinical practice. The book presents 16 manuscripts on sex differences of heart disease, as developed by several investigators; the volume is organized in four parts. Part I, dealing with sex differences in cardiac ischemic injury, includes 5 chapters on experimental aspects of cardiac ischemia/reperfusion injury, the role of testosterone, and clinical aspects of ischemic heart disease. Part II is devoted to sex differences in heart failure and includes four chapters. Discussion in this part of the book is centered around the sex differences in heart failure due to volume overload. Part III of this volume includes four papers on risk factors of cardiovascular diseases, namely hypertension and obesity, and, finally, three chapters in part IV deal with sex differences of cardiac mitochondria under different pathological conditions. We believe this book will be very useful for cardiovascular scientists, graduate students, postdoctoral fellows and other health professionals.
988 _aSpringer_BiomedLife_dic2020
650 7 _2embne
_aAparato circulatorio
_xEnfermedades
_9169062
650 7 _2embne
_aCorazón
_xEnfermedades
_9169667
700 1 _aOšt̕ádal, Bohuslav
_eeditor literario
_4http://id.loc.gov/vocabulary/relators/edt
_984615
700 1 _aDhalla, Naranjan S.
_eeditor literario
_4http://id.loc.gov/vocabulary/relators/edt
_984616
710 2 _aSpringerLink
773 0 _tSpringer Nature eBook
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-58677-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2020
_dz
_eb
_zSI