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003			ES-MaUEC
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008			190617s2020 gw | s |||| 0|eng d
020			_a9783319645971
024	7		_a10.1007/978-3-319-64597-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR182 _b2020 EB
245	0	0	_aHandbook of Immunosenescence : _bBasic Understanding and Clinical Implications _cedited by Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020.
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aReference Module Biomedical and Life Sciences (SpringerNature-43744)
505	0		_aMethods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms - Receptors and Signal Transduction -- Clinical Relevance in Disease States - Infection -- Modulation -- Nutrition.
520	3		_a"Immunosenescence" is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. Indeed, during the almost 10 years that have passed since the first edition of this Handbook, a wealth of additional information has emerged from animal models and also from increasingly available human data. Numerous new aspects of the immune changes with aging have emerged, while others became less prominent. The application of the new multi-"omics" techniques in immunology have revolutionized our molecular understanding of basic immune mechanisms. The extended and revisited concept of Inflamm-aging sheds a new light on the intricate relationships among immunosenescence and inflamm-aging. The new concept of inflamm-aging integrates different emerging experimental data such as those pertaining to the senescence-associated secretory phenotype and responses to damage. "Geroscience" is emphasising the role of immune changes during life in all manner of age-related chronic diseases such as cancer and neurodegenerative disorders. The field is poised to be in a position to translate these accumulated data into the clinical setting via a better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This new edition of the Handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in both basic research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, microbiome, lipids, vaccination and the burning question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?".
988			_aSpringer_BiomedLife_dic2020
650		7	_aInmunología _2embne _9138330
700	1		_aFulop, Tamas _eeditor _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aFranceschi, Claudio _eeditor _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHirokawa, Katsuiku _eeditor _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aPawelec, Graham _eeditor (orcid)0000-0002-3600-0163 _1https://orcid.org/0000-0002-3600-0163 _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
773	0		_tSpringer Nature Living Reference
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64597-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eo _zSI