000			04613nam a22004335i 4500
006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
999			_c329503 _d329503 _x1
001			329503
003			ES-MaUEC
005			20230102114416.0
008			201029s2020 gw | s |||| 0|eng d
020			_a9783030523213
024	7		_a10.1007/978-3-030-52321-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH450 _b2020 EB
100	1		_aCarlberg, Carsten _eauthor. _0(orcid)0000-0003-2633-0684 _1https://orcid.org/0000-0003-2633-0684 _4aut _4http://id.loc.gov/vocabulary/relators/aut _986297
245	1	0	_aMechanisms of Gene Regulation : _bHow Science Works _cCarsten Carlberg, Ferdinand Molnár.
250			_aFirst edition
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020.
300			_a1 recurso en línea (XVI, 149 páginas) _b71 ilustraciones, 70 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aCentral dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.
520	3		_aThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
988			_aSpringer_BiomedLife_dic2020
650		7	_aExpresión génica _2embne _9162770
700	1		_aMolnár, Ferdinand _eauthor. _0(orcid)0000-0001-9008-4233 _1https://orcid.org/0000-0001-9008-4233 _4aut _4http://id.loc.gov/vocabulary/relators/aut _998878
710	2		_aSpringerLink
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783030523206
776	0	8	_iPrinted edition: _z9783030523220
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-52321-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eo _zSI