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005			20230102114416.0
008			201028s2020 si | s |||| 0|eng d
020			_a9789811588075
024	7		_a10.1007/978-981-15-8807-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM301.5 _b2020 EB
245	0	0	_aCircadian Pharmacokinetics _cedited by Baojian Wu, Danyi Lu, Dong Dong.
250			_aFirst edition
264		1	_aSingapore _bSpringer Singapore : _bImprint: Springer _c2020.
300			_a1 recurso en línea (VII, 253 páginas) _b59 ilustraciones, 46 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aChapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
520	3		_aThis book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
988			_aSpringer_BiomedLife_dic2020
650		7	_aFarmacocinética _2embne _9145145
650		7	_aRitmos circadianos _2embne _9147045
650		7	_aFarmacología _2embne _9137893
700	1		_aWu, Baojian _eeditor _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aLu, Danyi _eeditor _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aDong, Dong _eeditor _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9789811588068
776	0	8	_iPrinted edition: _z9789811588082
776	0	8	_iPrinted edition: _z9789811588099
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-15-8807-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eo _zSI