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020 _a9789811569302
024 7 _a10.1007/978-981-15-6930-2
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC267
_b2020 EB
245 0 0 _aAutophagy in tumor and tumor microenvironment
_cedited by Sujit Kumar Bhutia.
250 _aFirst edition
264 1 _aSingapore
_bSpringer Singapore :
_bImprint: Springer
_c2020.
300 _a1 recurso en línea (VII, 280 páginas)
_b38 ilustraciones, 37 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505 0 _aChapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy - An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
520 3 _aThis book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy's role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
988 _aSpringer_BiomedLife_dic2020
650 7 _aCáncer
_xInvestigación
_2embne
_9182523
650 7 _aInmunología
_2embne
_9138330
650 7 _aResistencia a los medicamentos
_2embne
_9146972
700 1 _aBhutia, Sujit Kumar
_eeditor
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811569296
776 0 8 _iPrinted edition:
_z9789811569319
776 0 8 _iPrinted edition:
_z9789811569326
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-15-6930-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b01/2021
_dz
_eo
_zSI