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006			a||||fo|||| 00| 0
007			cr nn nnnaamaa
999			_c329485 _d329485 _x1
001			329485
003			ES-MaUEC
005			20230102114414.0
008			201020s2020 gw | s |||| 0|eng d
020			_a9783030576165
024	7		_a10.1007/978-3-030-57616-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR46 _b2020 EB
245	1	0	_aNecrotizing Soft Tissue Infections _bClinical and Pathogenic Aspects _cedited by Anna Norrby-Teglund, Mattias Svensson, Steinar Skrede
250			_aFirst edition 2020
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020.
300			_a1 recurso en línea (VIII, 207 páginas)
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1294
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aChapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections -- Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective -- Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician's perspectives -- Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects -- Chapter 5: Microbiological etiology of necrotizing soft tissue infections -- Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections -- Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics -- Chapter 8: Treatment of necrotizing soft tissue infections: IVIG -- Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections -- Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections -- Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections -- Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.
520	3		_aThis volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers' understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
988			_aSpringer_BiomedLife_dic2020
650		7	_2embne _aMicrobiología _9138684
700	1		_aNorrby-Teglund, Anna _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aSvensson, Mattias _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aSkrede, Steinar _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783030576158
776	0	8	_iPrinted edition: _z9783030576172
776	0	8	_iPrinted edition: _z9783030576189
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-57616-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eh _zSI