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007			cr nn nnnaamaa
008			201012s2020 si | s |||| 0|eng d
020			_a9789811577932
024	7		_a10.1007/978-981-15-7793-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC915 _b2020 EB
245	0	0	_aUremic Toxins and Organ Failure _cedited by Hideyuki Saito, Takaaki Abe
250			_aFirst edition 2020
264		1	_aSingapore _bSpringer International Publishing _c2020
300			_a1 recurso en línea (VIII, 180 páginas) _b39 ilustraciones, 22 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aarchivo de texto _bPDF
490	0		_aMedicine (SpringerNature-11650)
490	0		_aMedicine (R0) (SpringerNature-43714)
505	0		_a1 Overview of Uremic Toxins -- 2 Review: Uremic toxins and gut microbiome -- 3 Gut microbiota and systemic uremic solute accumulation -- 4 Uremic toxin-related systemic disorders -- 5 Uremic Toxins and cardiovascular disease -- 6 Indoxyl sulfate and arteriosclerosis -- 7 Uremic Toxicity and Bone in CKD -- 8 D-serine as a novel uremic toxin -- 9 Uremic solutes and sarcopenia -- 10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries -- 11 Accumulation of uremic toxins in systemic organs and the effect of AST-120.
520	3		_aThis book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.
988			_aSpringer_Medicine_2020
650		7	_2embne _9676989 _aUremia
700	1		_aSaito, Hideyuki _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aAbe, Takaaki _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9789811577925
776	0	8	_iPrinted edition: _z9789811577949
776	0	8	_iPrinted edition: _z9789811577956
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-15-7793-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_dz _b01/2021 _eIG _zSI