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007			cr nn nnnaamaa
008			200919s2020 gw | s |||| 0|eng d
020			_a9783030538682
024	7		_a10.1007/978-3-030-53868-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRD93 _b2020 EB
100	1		_aLand, W. _eauthor _0(orcid)0000-0002-0090-0629 _1https://orcid.org/0000-0002-0090-0629 _4aut _4http://id.loc.gov/vocabulary/relators/aut _9676879 _q(Walter)
245	1	0	_aDamage-Associated Molecular Patterns in Human Diseases : _bVolume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets _cWalter Gottlieb Land
250			_aFirst edition 2020
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XXXIX, 629 páginas) _b45 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aarchivo de texto _bPDF
490	0		_aMedicine (SpringerNature-11650)
490	0		_aMedicine (R0) (SpringerNature-43714)
505	0		_aPart I. Prologue -- Perspectives of the Danger/Injury Model in Immunology -- Part II. A Select, Clinically Oriented Update of Topics Presented in "Damage-Associated Molecular Patterns in Human Diseases"; Volume 1: Injury-Induced Innate Immune Responses -- Pattern Recognition Molecules -- The Growing World of DAMPs -- The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis -- Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases -- DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics -- DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma -- Solid Organ Injury -- Atherosclerosis -- Cerebro - Cardiovascular Diseases -- Part IV. Epilogue -- The "DAMPome" as a Key Player in the Pathogenesis of Human Diseases.
520	3		_aThis book is a continuance of the topic: "DAMPs in Human Diseases", the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs ("SAMPs") is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses .
988			_aSpringer_Medicine_2020
650		7	_aHeridas y lesiones _xAspectos inmunológicos _2embne _9139586
650		7	_aInmunología _2embne _9138330
650		7	_aInmunología _xTécnica _2embne _9676880
776	0	8	_iPrinted edition: _z9783030538675
776	0	8	_iPrinted edition: _z9783030538699
776	0	8	_iPrinted edition: _z9783030538705
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-53868-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_dz _b01/2021 _eo _zSI