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008			201001s2020 gw | s |||| 0|eng d
020			_a9783030447434
024	7		_a10.1007/978-3-030-44743-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP623 _b2020 EB
245	0	4	_aThe Chemical Biology of Long Noncoding RNAs _cedited by Stefan Jurga, Jan Barciszewski
250			_aFirst edition 2020
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020
300			_a1 recurso en línea (X, 544 páginas) _b49 ilustraciones, 45 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	1		_aRNA Technologies, _x2197-9731 ; _v11
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (SpringerNature-43708)
505	0		_aLong Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells' Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation.
520	3		_aThis book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
988			_aSpringer_BiomedLife_13102020
650		7	_2embne _aARN _9144940
650		7	_2embne _9147235 _aTranscripción genética
700	1		_aJurga, Stefan _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBarciszewski, Jan _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
776	0	8	_iPrinted edition: _z9783030447427
776	0	8	_iPrinted edition: _z9783030447441
776	0	8	_iPrinted edition: _z9783030447458
830		0	_aRNA Technologies, _x2197-9731 ; _v11
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-44743-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eIG _zSI