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005			20230102114255.0
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007			cr nn nnnaamaa
008			200928s2020 gw | s |||| 0|eng d
020			_a9783030538217
024	7		_a10.1007/978-3-030-53821-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC280.C6 _b2020 EB
245	0	0	_aIlluminating Colorectal Cancer Genomics by Next-Generation Sequencing : _bA Big Chapter in the Tale _cedited by Khalid El Bairi
250			_aFirst edition
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020
300			_a1 recurso en línea (XV, 185 páginas) : _b26 ilustraciones, 25 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (SpringerNature-43708)
505	0		_aAn Introduction to the Current Management of Colorectal Cancer in the Era of Personalized Oncology -- Colorectal Cancer Genetics: An Overview of the Actionable Building Blocks -- The Arrival of Next-Generation Sequencing: An Overview of Current Technologies -- Next-Generation Sequencing for Colorectal Cancer Management -- Gut Microbiota, Next-Generation Sequencing, Immune Checkpoint Inhibitors and Colorectal Cancer: How Hot is the Link? -- The Revolution of Liquid Biopsy and Single-Cell Sequencing in the Management of Colorectal Cancer -- Overview of Cost-Effectiveness and Limitations of Next-Generation Sequencing in Colorectal Cancer.
520	3		_aThis book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care
988			_aSpringer_BiomedLife_13102020
650		7	_aColon _xCáncer _2embne _9182269
650		7	_aRecto _xCáncer _2embne _9182442
650		7	_aCáncer _xAspectos genéticos _2embne _9273952
700	1		_aEl Bairi, Khalid _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
776	0	8	_iPrinted edition: _z9783030538200
776	0	8	_iPrinted edition: _z9783030538224
776	0	8	_iPrinted edition: _z9783030538231
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-53821-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eo _zSI