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007			cr nn nnnaamaa
008			200919s2020 si | s |||| 0|eng d
020			_a9789811544941
024	7		_a10.1007/978-981-15-4494-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP624.5.M46 _b2020 EB
245	0	0	_aSingle-cell Sequencing and Methylation : _bMethods and Clinical Applications _cedited by Buwei Yu, Jiaqiang Zhang, Yiming Zeng, Li Li, Xiangdong Wang
250			_aFirst edition
264		1	_aSingapore _bSpringer Singapore : _bImprint: Springer _c2020
300			_a1 recurso en línea (VIII, 247 páginas) : _b117 ilustraciones, 114 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1255
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (SpringerNature-43708)
505	0		_aValues of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.
520	3		_aWith the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
988			_aSpringer_BiomedLife_13102020
650		7	_aADN mitocondrial _2embne _9670608
650		7	_aDiagnóstico molecular _2embne _9158916
650		7	_aBioinformática _2embne _9160489
700	1		_aYu, Buwei _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZhang, Jiaqiang _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aZeng, Yiming _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aLi, Li _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aWang, Xiangdong _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink
776	0	8	_iPrinted edition: _z9789811544934
776	0	8	_iPrinted edition: _z9789811544958
776	0	8	_iPrinted edition: _z9789811544965
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1255
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-15-4494-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2021 _dz _eo _zSI