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020 _a9783030521233
024 7 _a10.1007/978-3-030-52123-3
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQR46
_b2020 EB
245 0 0 _aBacterial Type III Protein Secretion Systems
_cedited by Samuel Wagner, Jorge E. Galan
250 _aFirst edition 2020
264 1 _aCham
_bSpringer International Publishing
_c2020
300 _a1 recurso en línea (VIII, 230 páginas)
_bilustraciones
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aCurrent Topics in Microbiology and Immunology
_x0070-217X
_v427
490 0 _aBiomedical and Life Sciences (SpringerNature-11642)
490 0 _aBiomedical and Life Sciences (SpringerNature-43708)
505 0 _aIntroduction -- Evolution of type III secretion systems -- Transcriptional and post-transcriptional regulatory mechanisms controlling type III secretion -- Assembly of type III secretion machines -- Structure of the type III secretion needle complex -- Structure and assembly of filamentous structures associated with type III secretion machines -- Structure and function of the type III secretion-associated sorting platform -- Molecular organization and assembly of the protein export apparatus -- Export mechanisms and energy transduction in type III secretion machines -- Needle length control and substrate switching in type III secretion machines -- The tip complex: sensing the host cell -- Chaperones and targeting mechanisms
520 3 _aOne of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen's benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.
988 _aSpringer_BiomedLife_13102020
650 7 _2embne
_9138907
_aBacteriología
700 1 _aWagner, Samuel
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGalan, Jorge E
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink
776 0 8 _iPrinted edition:
_z9783030521226
776 0 8 _iPrinted edition:
_z9783030521240
776 0 8 _iPrinted edition:
_z9783030521257
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-52123-3
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b11/2020
_dz
_ek
_zSI