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008			200714s2020 gw a o |||| 0|eng d
020			_a9783030482831
024	7		_a10.1007/978-3-030-48283-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC267 _b2020 EB
245	0	0	_aNext Generation Kinase Inhibitors : _bMoving Beyond the ATP Binding/Catalytic Sites _cedited by Paul Shapiro
250			_aFirst edition
264		1	_aCham _bImprint: Springer _c2020
264		1	_aCham _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XII, 217 páginas) _b59 ilustraciones, 56 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aBiomedical and Life Sciences (R0) (SpringerNature-43708)
505	0		_aChapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index.
520			_aProtein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. .
988			_aSpringer_Biomedlife_03082020
650		7	_2embne _aCáncer _xInvestigación _9182523
700	1		_aShapiro, Paul _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt _0http://id.loc.gov/authorities/names/no00004895 _1http://viaf.org/viaf/59285905 _9675296
776	0	8	_iPrinted edition: _z9783030482824
776	0	8	_iPrinted edition: _z9783030482848
776	0	8	_iPrinted edition: _z9783030482855
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-48283-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b08/2020 _dz _ek _zSI