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008			200713s2020 gw a o |||| 0|eng d
020			_a9783319688640
024	7		_a10.1007/978-3-319-68864-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM301.25 _b2020 EB
245	0	0	_aDrug Discovery and Evaluation : _bMethods in Clinical Pharmacology _cedited by Franz J. Hock, Michael R. Gralinski
250			_aSecond edition
264		1	_aCham _bImprint: Springer _c2020
264		1	_aCham _bSpringer International Publishing _c2020
300			_a1 recurso en línea _b249 ilustraciones, 179 ilustraciones en color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (SpringerNature-11642)
490	0		_aReference Module Biomedical and Life Sciences (SpringerNature-43744)
520			_aThis is the second edition of a well-received book in the series "Drug Discovery and Evaluation" The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: "Methods in Clinical Pharmacology". For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.
988			_aSpringer_Biomedlife_03082020
650		7	_2embne _9137892 _aMedicamentos _xInvestigación
650		7	_2embne _aFarmacología _9137893
700			_aHock, Franz Jakob _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/305404895 _985329
700	1		_aGralinski, Michael R. _eeditor literario _4http://id.loc.gov/vocabulary/relators/edt _9675277
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-68864-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b08/2020 _dz _ek _zSI