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020 _a9789811547980
024 7 _a10.1007/978-981-15-4798-0
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC388.5
_b2020 EB
100 1 _aG. K., Rajanikant
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_9675047
245 1 0 _aIschemiRs :
_bMicroRNAs in Ischemic Stroke : From Basics to Clinics
_cRajanikant G. K., Pierre Gressens, Sreekala S. Nampoothiri, Gokul Surendran, Cindy Bokobza
250 _aFirst edition
264 1 _aSingapore
_bSpringer International Publishing
_c2020
300 _a1 recurso en línea (XVI, 138 páginas)
_b7 ilustraciones, 6 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aBiomedical and Life Sciences (Springer-11642)
505 0 _aPreface -- Chapter 1: microRNAs in normal brain physiology -- Chapter 2: Ischemic stroke: An imperative need for effective therapy -- Chapter 3: MicroRNAs in ischemic stroke pathophysiology: Special emphasis on early molecular events -- Chapter 4: microRNA regulation of ischemic stroke inflammatory and immune response -- Chapter 5: Regulatory role of microRNAs in ischemic cell death -- Chapter 6: The emerging role of microRNAs in post-ischemic angiogenesis and neurogenesis -- Chapter 7: MicroRNAs as potential diagnostic, prognostic and therapeutic biomarkers in ischemic stroke -- Chapter 8: Interplay between microRNAs and other cerebrovascular diseases -- Chapter 9: New insights into the regulatory role of lncRNA, circRNA, piRNAs, and ceRNAs in ischemic stroke -- Chapter 10: Computational resources for microRNA research -- Chapter 11: MicroRNA-targeted therapeutics for ischemic stroke: Status, gaps and the way forward.
520 3 _aThere has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and ischemic stroke, the more prevalent of the two main types of stroke. The chapters address questions relating to microRNA's function in various pathological features of stroke, like oxidative stress, excitotoxicity and cell death, as well as its role as a biomarker and diagnostic agent, and the current therapeutic interventions. Further, the book highlights the latest research on how miRNAs contribute to neuroregeneration following stroke, discussing the myriad computational tools and databases used in miRNA research, and decsribes how how miRNA modulates other cerebrovascular diseases. The book concludes with fresh insights into the effect of long non-coding RNA in cerebral ischemia.
988 _aSpringer_Biomedlife_23062020
650 7 _aIsquemia cerebral
_2embne
_9144257
650 7 _aApoptosis
_2embne
_9157983
650 7 _aMicroARNs
_2embne
_9668119
700 1 _aGressens, Pierre
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_1http://viaf.org/viaf/39599829
_9675048
700 1 _aNampoothiri, Sreekala S
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_9675049
700 1 _aSurendran, Gokul
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_9675050
700 1 _aBokobza, Cindy
_eautor
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_9675051
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_1http://viaf.org/viaf/148105729
776 0 8 _iPrinted edition:
_z9789811547973
776 0 8 _iPrinted edition:
_z9789811547997
776 0 8 _iPrinted edition:
_z9789811548000
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-15-4798-0
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b07/2020
_dz
_eo
_zSI