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008			200512s2020 gw a o |||| 0|eng d
020			_a9783030404062
024	7		_a10.1007/978-3-030-40406-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR187.P4 _b2020 EB
245	0	0	_aMolecular and Cellular Biology of Phagocytosis _cedited by Maurice B. Hallett
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (X, 189 páginas) _b66 ilustraciones, 58 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1246
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aAn introduction to phagocytosis -- A Brief History of Phagocytosis -- The role of membrane surface charge in phagocytosis -- Receptor models of phagocytosis: the effect of target shape -- Decision Making in Phagocytosis -- Membrane tension and the role of ezrin during phagocytosis -- Molecular mechanisms of calcium signaling during phagocytosis -- Calpain activation by Ca2+ and its role in phagocytosis -- The NADPH oxidase and the phagosome -- Conclusions and the future of phagocytosis.-.
520	3		_aPhagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably "primitive") cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the "natural" immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
988			_aSpringer_Biomedlife_23062020
650		7	_aFagocitosis _2embne _9674677
700	1		_aHallett, Maurice B _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt _1http://viaf.org/viaf/74587547
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729
776	0	8	_iPrinted edition: _z9783030404055
776	0	8	_iPrinted edition: _z9783030404079
776	0	8	_iPrinted edition: _z9783030404086
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1246
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-40406-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b07/2020 _dz _eo _zSI