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008			200403s2020 gw a o |||| 0|eng d
020			_a9783030416799
024	7		_a10.1007/978-3-030-41679-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP529 _b2020 EB
100	1		_aChen, Chang-Hwei _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _0http://id.loc.gov/authorities/names/n2012182830 _1http://viaf.org/viaf/232766081 _9674553
245	1	0	_aXenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense / _cChang-Hwei Chen.
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XVII, 239 páginas) _b53 ilustraciones, 3 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aOverview -- Foreign Compounds: Foods, Drugs and Other Chemicals -- Absorption, Metabolism and Excretion of Foreign Compounds -- Metabolism of Foreign Compounds -- Bioactivation Metabolism: Activation Enzymes -- Functionalization Reactions Catalyzed by Activation Enzymes -- Detoxifying Metabolism: Detoxification Enzymes -- Conjugation Reactions Catalyzed by Detoxification Enzymes -- Reactive Intermediates Generated from Bioactivation -- Electrophilic Nature of Metabolic Reactive Intermediates -- Oxidative Stress Mediated by Reactive Intermediates -- Xenobiotics Bioactivation - Mediated Cellular Damages -- Nrf2 - ARE Pathway: Defense Against Oxidative Stress -- Genetic Variations and Polymorphisms of Metabolic Enzymes -- Enzyme Polymorphisms Affecting Xenobiotic Toxicity -- Inducibility of foreign Compound Metabolic Enzymes -- Induction of Enzymes for Health Benefits -- Diversity of Metabolic Enzyme Modulators -- Dietary Inducers of Detoxification Enzymes.
520	3		_aThis book provides a comprehensive, organized, and concise overview of Xenobiotic Metabolic Enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 - ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.
988			_aSpringer_Biomedlife_23062020
650		7	_aXenobióticos _2embne _9671892
650		7	_aEnzimas _2embne _9138640
650		7	_aMetabolismo _2embne _9138638
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729
776	0	8	_iPrinted edition: _z9783030416782
776	0	8	_iPrinted edition: _z9783030416805
776	0	8	_iPrinted edition: _z9783030416812
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-41679-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b06/2020 _dz _eo _zSI