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008			200507s2020 gw a o |||| 0|eng d
020			_a9783030412838
024	7		_a10.1007/978-3-030-41283-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH467 _b2020 EB
245	0	0	_aMechanisms of Genome Protection and Repair / _cedited by Dmitry O. Zharkov.
250			_aFirst edition
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XVI, 220 páginas) _b30 ilustraciones, 20 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1241
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aPreface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix-Hairpin-Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health -- Biotransformation and Toxicities of Aristolochic Acids -- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses -- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.
520	3		_aThis volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein-DNA interactions that ensure fast and reliable discrimination between targets - be it DNA modifications or specific sequences - and non-targets. Examples of particular proteins and their function in repair regulation, translesion synthesis and chromatin remodeling are discussed in the following three chapters. Next, more attention is given to the mutagenic consequences of failed or aberrant DNA repair, particularly in mitochondria and in runs of trinucleotide repeats. Moving to a human health-oriented view, the book presents data on two kinds of lesions, the widely found 8-oxoguanine and the dietary genotoxic adducts with aristolochic acids, as biomarkers of general oxidative stress and specific exposure, respectively. Two final chapters are devoted to the interplay of multiple factors, including genotoxic stress, in the complex phenotypes in humans (amyotrophic lateral sclerosis ) and plants (abiotic stress response). This volume will be of significant interest for scientists working in the field of DNA repair as well as for the general biochemistry and molecular biology audience.
988			_aSpringer_Biomedlife_23062020
650		7	_aADN _xReplicación _2embne _9301511
700	1		_aZharkov, Dmitry O _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729
776	0	8	_iPrinted edition: _z9783030412821
776	0	8	_iPrinted edition: _z9783030412845
776	0	8	_iPrinted edition: _z9783030412852
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1241
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-41283-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b06/2020 _dz _eo _zSI