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020 _a9783030379728
024 7 _a10.1007/978-3-030-37972-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC889
_b2020 EB
245 1 0 _aGenetics of Male Infertility
_bA Case-Based Guide for Clinicians
_cedited by Mohamed Arafa, Haitham Elbardisi, Ahmad Majzoub, Ashok Agarwal.
250 _aFirst edition 2020
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2020.
300 _a1 recurso en línea (XVII, 375 páginas)
_b54 ilustraciones, 51 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aMedicine (Springer-11650)
505 0 _aPart I: The Genetic Basis of Reproduction -- The Molecular Genetics of Testis Determination -- Molecular Regulation of Sperm Production Cascade -- Spermatozoal Chromatin Structure: Role in Sperm Functions and Fertilization -- Genetic Basis of Endocrine Regulation of Spermatogenesis -- Epidemiology of Genetic Disorders in Male Infertility -- Genetic Evaluation of Male Infertility -- Part II: Impact of Genetics on the Sperm Cell -- Genetic Basis of Sperm Morphologic Defects: Head Defects, Body and Tail Defects -- Mitochondrial Function and Male Infertility -- Sperm DNA Fragmentation and Male Infertility -- The Sperm Epigenome and Potential Implications for the Developing Embryo -- Part III: Clinical Case Scenarios -- Klinefelter Syndrome -- Chromosomal Translocations and Inversion in Male Infertility -- Genetics of Vas Aplasia -- Anomalies of the Y Chromosome -- Infertility and Cryptorchidism -- Kartagener and Immotile Cilia Syndrome -- Persistent Müllerian Duct Syndrome -- Disorders of Sex Determination -- Endocrine Genetic Defects -- Sperm Aneuploidy -- Part IV: Genetic Infertility: Is There Any Hope?- Sperm DNA Fragmentation -- The Potential of CRISPR/Cas Gene Editing to Correct Male Infertility.
520 3 _aThis unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.
988 _aSpringer_Medicine_2020
650 7 _2embne
_aEsterilidad
_9140533
650 7 _2embne
_aSalud reproductiva
_9162207
700 1 _aArafa, Mohamed.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aElbardisi, Haitham.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMajzoub, Ahmad.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/n2018184631
_1http://viaf.org/viaf/23152864060704820100
700 1 _aAgarwal, Ashok.
_eeditor literario
_0(orcid)0000-0003-0585-1026
_1https://orcid.org/0000-0003-0585-1026
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_0http://id.loc.gov/authorities/names/nb2011002412
_1http://viaf.org/viaf/165944699
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_1http://viaf.org/viaf/148105729
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783030379711
776 0 8 _iPrinted edition:
_z9783030379735
776 0 8 _iPrinted edition:
_z9783030379742
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-37972-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b05/2020
_dz
_ea
_zSI