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008			200207s2020 gw | o |||| 0|eng d
020			_a9783030306519
024	7		_a10.1007/978-3-030-30651-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aRC280.B7 _b2020 EB
245	0	0	_aGlioma Signaling _cedited by Jolanta Barańska
250			_aSecond edition 2020
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XI, 305 páginas) _b48 ilustraciones, 36 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v1202
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_aIntroduction to purinergic signaling in the brain -- Adenosine signaling in glioma cells -- Cross-talk in nucleotide signaling in glioma c6 cells -- Calcium signaling in glioma cells - the role of nucleotide receptors -- Purinergic signaling in glioma progression -- Cytoskeleton and nucleotide signaling in glioma c6 cells -- Signaling determinants of glioma cell invasion -- Receptor tyrosine kinases: principles and functions in glioma invasion -- Recent advances in understanding mechanisms of tgf beta signaling and its role in glioma pathogenesis -- Stat signaling in glioma cells -- Cannabinoid signaling in glioma cells -- Effects of arginine and its deprivation on human glioblastoma physiology and signaling -- Histone modifying enzymes and chromatin modifiers in glioma pathobiology and therapy responses -- Role of infiltrating microglia/macrophages in glioma. .
520	3		_aGliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
988			_aSpringer_BiomedLife_31032020
650		7	_2embne _9214753 _aCerebro _xTumores
650		7	_2embne _9144370 _aGlioma
700	1		_aBarańska, Jolanta. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
776	0	8	_iPrinted edition: _z9783030306502
776	0	8	_iPrinted edition: _z9783030306526
776	0	8	_iPrinted edition: _z9783030306533
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://dx.doi.org/10.1007/978-3-030-30651-9
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI