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008			200214s2020 gw | o |||| 0|eng d
020			_a9783030369484
024	7		_a10.1007/978-3-030-36948-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
041	0		_aeng
050		4	_aQP144.G45 _b2020 EB
100	1		_aCarlberg, Carsten _eautor _986297
245	1	0	_aNutrigenomics : _bHow Science Works _cby Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár
250			_aFirst edition 2020
264		1	_aCham, Switzerland _bSpringer International Publishing _c2020
300			_a1 recurso en línea (XXI, 181 páginas) _b70 ilustraciones, 69 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aBiomedical and Life Sciences (Springer-11642)
505	0		_a1.Nutrition and common diseases -- 1.1.Evolution of human nutrition -- 1.2.Principles of metabolism -- 1.3.Dietary molecules -- 1.4.Nutrition and metabolic diseases -- 1.5.Nutrition and cancer -- 1.6.Impact of physical activity -- 2.Human genomic variation -- 2.1.Migration and evolutionary challenges of Homo sapiens -- 2.2.Diversity of human populations -- 2.3.Genetic variants of the human genome -- 2.4.Haplotype blocks and GWAS -- 2.5.The 1000 Genomes Project -- 3.Sensing nutrition -- 3.1.Nutrient-sensing mechanisms -- 3.2.Nuclear receptors as nutrient sensors -- 3.3.Functions and actions of PPARs -- 3.4 Integration of lipid metabolism by LXRs and FXR -- 3.5.Coordination of the immune response by VDR -- 3.6.Circadian control of metabolic processes -- 4.Interference of the human genome with nutrients -- 4.1.Human genetic adaptions -- 4.2.Genetic adaption to dietary changes -- 4.3 Regulatory SNPs and quantitative traits -- 4.4.Nutrigenomic analysis -- 4.5 Personal omics profiles -- 5.Nutritional epigenetics -- 5.1.Epigenetic mechanisms -- 5.2.Intermediary metabolism and epigenetic signaling -- 5.3.Nutrition-triggered transgenerational epigenetic inheritance -- 5.4.Population epigenetics -- 6.Nutritional signaling and aging -- 6.1 Aging and conserved nutrient-sensing pathways -- 6.2.Neuroendocrine regulation of aging -- 6.3.Principles of insulin signaling -- 6.4.Central role of FOXO transcription factors -- 6.5.Caloric restriction from yeast to mammals -- 6.6.Cellular energy status sensing by sirtuins and AMPK -- 7.Chronic inflammation and metabolic stress -- 7.1 Central role of monocytes and macrophages -- 7.2.Acute and chronic inflammation -- 7.3.Reverse cholesterol transport and inflammation -- 7.4.Sensing metabolic stress via the ER -- 8.Obesity -- 8.1 Definition of obesity -- 8.2 Adipogenesis -- 8.3.Inflammation in adipose tissue -- 8.4.Energy homeostasis and hormonal regulation of food uptake -- 8.5.Genetics of obesity -- 9.Insulin resistance and diabetes -- 9.1.Glucose homeostasis -- 9.2.Insulin resistance in skeletal muscle and liver -- 9.3.β cell failure -- 9.4.Definition of diabetes -- 9.5.Disturbed glucose homeostasis in T2D and its treatment -- 9.6.Genetics and epigenetics of T2D -- 10.Heart disease and the metabolic syndrome -- 10.1.Hypertension -- 10.2.Mechanisms of atherosclerosis -- 10.3.Lipoproteins and dyslipidemias -- 10.4.Whole body's perspective of the metabolic syndrome -- 10.5.Metabolic syndrome in key metabolic organs -- 10.6.Genetics and epigenetics of the metabolic syndrome.-.
520	3		_aThe fascinating area of Nutrigenomics describes this daily communication between our diet and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannahs of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life and our life-long "chat" with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. The content of this book is based on the lecture course "Nutrigenomics", which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book represents an updated but simplified version of our textbook "Nutrigenomics" (ISBN 978-3-319-30413-7). Besides its value as a textbook, "Nutrigenomics: how science works" will be a useful reference for individuals working in biomedicine.
988			_aSpringer_BiomedLife_31032020
650		7	_2embne _9446830 _aNutrición _xAspectos genéticos
650		7	_2embne _9162770 _aExpresión génica
700	1		_aUlven, Stine Marie _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _998877
700	1		_aMolnár, Ferdinand _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _998878
710	2		_aSpringerLink (Online service)
776	0	8	_iPrinted edition: _z9783030369477
776	0	8	_iPrinted edition: _z9783030369491
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://dx.doi.org/10.1007/978-3-030-36948-4
942			_2lcc _cLE _n0
998			_b04/2020 _dz _eb _zSI